魏京广
个人简介:
男,博士,研究员,广东省特支计划百千万工程青年拔尖人才。研究方向:海水鱼类抗病免疫机制及抗病制品的研制。主持完成国家自然科学基金青年基金、面上项目、973子课题等项目;在Frontiers in Immunoloogy、BMC Genomics、Cellular Microbiology、Frontiers in Microbiology等本领域重要期刊发表30多篇论文;参与授权国家发明专利3件;参与编写专著2部。
工作经历:
2010.7-2012.11 中国科学院南海海洋研究所 助理研究员
2012.12-2017.6 中国科学院南海海洋研究所 副研究员
2017.7- 今 beat365中国在线体育 研究员
教育经历:
2000.9-2004.6 鲁东大学 生物科学本科
2004.9-2007.6 江西农业大学 微生物学硕士
2007.9-2010.6 中山大学 海洋生物学博士
获奖、荣誉称号:
1、广东省特支计划“科技创新青年拔尖人才”
2、中国科学院青年促进会会员
研究领域:
海洋鱼类抗病毒天然免疫及病害防控、水生动物健康养殖、海洋微生物学
科研项目:
(1)国家自然科学基金面上基金:石斑鱼PIAS1调控病毒诱导的I型干扰素表达的分子机制(31572643),2016.01-2019.12,在研,主持;
(2)广东省特支计划“科技创新青年拔尖人才”:2016.6-2018.5,在研,主持;
(3)中国科学院青年促进会会员: 2015.1 -2018.12,在研,主持;
(4)中国科学院先导专项专题:深海微生物工业酶的深入挖掘,2014.1 -2017.12,在研,主持;
(5)科技部863项目:海水养殖鱼类主要病毒和细菌性病原亚单位疫苗的研发 2014.04-2016.12,已结题,主持;
(6)国家科技计划项目-国家星火计划子课题:南方主要鱼类健康养殖技术集成与示范(2013GA780001)2013.1-2014.12,已结题,主持;
(7)国家自然科学基金青年基金:石斑鱼肿瘤坏死因子受体相关因子6(TRAF6)在抗病毒天然免疫反应中的作用(31202022)2013.01-2015.12,已结题,主持;
(8)广东省自然科学基金博士启动基金:石斑鱼肿瘤坏死因子超家族新成员TTRAP 的抗病毒功能研究(S2011040000953)2011.10-2013.10,已结题,主持;
(9)广州市科技计划项目:石斑鱼免疫抗病功能基因制品的研发(2014J4100213) 2014.04-2016.04,已结题,主持;
(10)中国科学院南海海洋研究所青年人才领域前沿项目-优秀青年基:石斑鱼抗氧化蛋白酶peroxiredoxin IV的克隆表达及在炎症反应中的作用研究(SQ201203) 2012.12 -2015.11,已结题,主持。
发表论文:
(1)Wei JG, Zang SQ, Xu M, Zheng QJ, Chen XL, *Qin QW. TRAF6 is a critical factor in fish immune response to virus infection. Fish & Shellfish Immunology,2017(60): 6-12
(2)Xie HW, Wei JG, *Qin QW. Antiviral function of Tachyplesin I against iridovirus and nodavirus. Fish & Shellfish Immunology, 2016 (58) 96-102. (共同第一作者)
(3) Chen XL, *Wei JG, Xu M, Yang M, Lei PF, Wei SN, Huang YH, *Qin QW.Molecular cloning and characterization of a galectin-1 homolog in orange-spotted grouper, Epinephelus coioides. Fish & Shellfish Immunology, 2016 (54) 333-341(共同通讯作者).
(4) Xu M, *Wei JG, Chen XL, Gao P, Zhou RC, *Qin QW. Molecular cloning and expression analysis of small ubiquitin-like modifier (SUMO) genes from grouper (Epinephelus coioides).Fish & Shellfish Immunology, 2016 (48) 119-127(共同通讯作者).
(5) WeiJ G, Xu M, Chen XL,Zhang P, Li PF, Wei SN, Yan Y, *Qin QW. Function analysis of fish Tollip gene in response to virus infection. Fish & Shellfish Immunology, 2015 (47) 807-816.
(6)Wei JG, Zhang P, Guo ML, Xu M, Li PF, Chen XL, Gao P, Wei SN, *Qin QW. TTRAP is a critical factor in grouper immune response to virus infection. Fish & Shellfish Immunology, 2015, 46:274-284.
(7)Wei JG, Gao P, Zhang P, Guo ML, Xu M, Wei SN, Yan Y, *Qin QW. Isolation and function analysis of apolipoprotein A-I gene response to virus infection in grouper. Fish & Shellfish Immunology, 2015, 43:396-404.
(8)Ji HS, Wei JG, Wei SN, Yan Y, Huang YH, Huang XH, Zhou S, Zhou RC, *Qin QW. Molecular cloning and expression of a C-type lectin-like protein from orange-spotted grouper Epinephelus coioides. Journal of Fish Biology, 2014, 84, 436–447(共同第一作者).
(9)Wei JG, Guo ML, Gao P, Ji HS, Li PF, Yan Y, *Qin QW. Isolation and characterization of tumor necrosis factor receptorassociated factor 6 (TRAF6) from grouper, Epinephelus tauvina. Fish & Shellfish Immunology, 2014, 39:61-68.
(10)Wei JG, Ji HS, Guo ML, Yan Y, *Qin QW. Identification and characterization of TRP14, a thioredoxin-related protein of 14 kDa from orange-spotted grouper, Epinephelus coioides. Fish & Shellfish Immunology, 2013, 35:1670-1676.
(11)Wei JG, Guo ML, Ji HS, *Qin QW. Molecular cloning, characterization of one key molecule of teleost innate immunity from orange-spotted grouper (Epinephelus coioides): serum amyloid A. Fish and Shellfish Immunology. 2013, 34: 296-304.
(12)Wei JG, Guo ML, Ji HS, Yan Y, Ouyang ZL, Huang XH, Hang YH, *Qin QW. Cloning, characterization, and expression analysis of a thioredoxin from orange-spotted grouper (Epinephelus coioides). Developmental & Comparative Immunology.2012, 38:108-116.
(13)Wei JG, Ji HS, Guo ML, *Qin QW. Isolation and characterization of a thioredoxin domain-containing protein 12 from orange-spotted grouper, Epinephelus coioides. Fish & Shellfish Immunology. 2012,33:667-673.
(14) Wei JG, Guo ML, Ji HS, Yan Y, Ouyang ZL, Huang XH, Hang YH, *Qin QW. Grouper translationally controlled tumor protein prevents cell death and inhibits the replication of Singapore grouper iridovirus (SGIV). Fish & Shellfish Immunology. 2012, 33:916-925.
(15)Wei JG, Guo ML, Cui HC, Yan Y, Ouyang ZL, *Qin QW. A new leukocyte cell-derived chemotaxin-2 from marine fish grouper, Epinephelus coioides: Molecular cloning and expression analysis. Fish & Shellfsih Immunology. 2011.31: 600-605.
(16) Wei JG, Xu D, Zhou JG, Cui HC, Yan Y, Ouyan ZL, Gong J, Huang YH, Huang XH, *Qin QW. Molecular cloning, characterization and expression analysis of a C-type lectin (Ec-CTL) in orange-spotted grouper, Epinephelus coioides. Fish & Shellfish Immunology. 2010. 28(1): 178-186.
(17)一种石斑鱼Epinecidin-1多肽及其应用,申请号201610329569.1,发明专利,魏京广、秦启伟、黄友华,申请。
(18)一种石斑鱼Pisacidin-4多肽及其应用,申请号201610326355.9,发明专利,魏京广、秦启伟、黄友华,申请。
(19)石斑鱼翻译控制肿瘤蛋白TCTP及其编码基因在抗鱼类神经坏死病毒方面的应用,申请号201410783832.5,发明专利,魏京广、秦启伟、周胜、许濛,申请。
(20)一种石斑鱼虹彩病毒(SGIV)灭活疫苗的转瓶生产方法,ZL201210240292.7,秦启伟,欧阳征亮,魏京广,黄晓红;发明专利,授权。
(21)一种红树林克雷伯氏菌及其在发酵法生产1,3-丙二醇中的应用,ZL201210053231.X ,周胜,秦启伟,魏京广,李莉莉,付静; 发明专利,授权。